On the east-northeast it is accessible to and from the Cities of Tangub, Ozamis, Oroquieta, Dapitan & Dipolog, Iligan and Cagayan de Oro by Bus via two separate routes, namely: the Pagadian-Molave-Osamis-Dipolog and Pagadian-Aurora-Illigan-Cagayan de Oro routes. On the west-northwest, the city is accessible to and from the City of Zamboanga and the Province of Zamboanga Sibugay, and on the southwest, to and from Zamboanga City via Margosatubig and Malangas.
Pagadian has a sister City in the State of New South Wales, Australia, the City of Cooma. This has been effective by virtue of confirming resolution adopted by the Municipal Council of Cooma on April 14, 1975 and resolution No. 41 dated July 21, 1975 of the City Board of Pagadian. This sister-city relationship has been established through the Philippine-Australian Development Assistance Programme being with contract with the Snowy Mountains Engineering Corporation, based in the City of Cooma, which undertook development projects within the Province of Zamboanga del Sur. The PADAP officials, technical men and crews, made Pagadian City their home-base, more particularly at Barangay Dao, this beautiful City of Pagadian.